Added: Nicola Samayoa - Date: 17.12.2021 14:20 - Views: 13322 - Clicks: 3178
Dextromethorphan has been reported to ameliorate opioid withdrawal symptoms in both animal and human subjects. In the present study, we investigated the efficacy of dextromethorphan as an add-on medication in heroin detoxification treatment in a double-blind, placebo-controlled de. Sixty-five heroin-dependent patients male, 63; female, 2 participated in this inpatient detoxification trial after giving informed consent. Clonidine 0. Each patient was then randomly ased to treatment with either dextromethorphan 60 mg or placebo 4 times a day as additional medication.
Flurazepam 30 mg was given before bedtime for insomnia. Other medications that were allowed included loperamide for diarrhea and lorazepam for agitation. Participants were monitored using the Objective Opioid Withdrawal Scale 3 times a day as the primary outcome to compare drug efficacy between groups.
There was no difference in the Clinical Global Impression Scale, patient's impression of treatment, and use of ancillary medications between groups. No severe adverse effects Dxm opiate withdrawal dosage noticed. We suggest that dextromethorphan has some beneficial effect in attenuating the severity of opioid withdrawal symptoms and can be used as an adjunction medication in the treatment of opioid withdrawal, whereas the exact efficacy needs further investigation.
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Send even when there aren't any new. Optional text in :. Save Cancel. Create a file for external citation management software Create file Cancel. of items displayed: 5 10 15 20 50 Create RSS Cancel. RSS Link Copy. Full text links Cite Display options Display options. J Clin Psychopharmacol. PMID: No abstract available. Abstract Dextromethorphan has been reported to ameliorate opioid withdrawal symptoms in both animal and human subjects. Similar articles Venlafaxine for acute heroin detoxification: a double-blind, randomized, control trial. Lin SK, et al. Dextromethorphan and quinidine combination for heroin detoxification.
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Lack of efficacy of dextromethorphan in managing alcohol withdrawal: a preliminary report of a randomized, double-blind, placebo-controlled trial. Huang MC, et al. Intentional intrathecal opioid detoxification in 3 patients: characterization of the intrathecal opioid withdrawal syndrome. Jackson TP, et al. Pain Pract. Epub Aug PMID: Review. Ibogaine in the treatment of heroin withdrawal.
Mash DC, et al. Alkaloids Chem Biol. No abstract available. See all similar articles. Cited by 5 articles Efficacy of montmorillonite and vitamin AD combined with zinc preparation in children with diarrheal disease and its effect on inflammatory factors. Wang Z, et al. Am J Transl Res. Dunn KE, et al. J Pharmacol Exp Ther. Epub Aug 7. Gowing L, et al. Cochrane Database Syst Rev. Arout CA, et al. CNS Drugs. A placebo-controlled trial of dextromethorphan as an adjunct in opioid-dependent patients undergoing methadone maintenance treatment.
Lee SY, et al. Int J Neuropsychopharmacol. Publication types Randomized Controlled Trial Actions. Research Support, Non-U. Gov't Actions. MeSH terms Adult Actions. Double-Blind Method Actions. Drug Therapy, Combination Actions. Female Actions. Humans Actions. Male Actions. Middle Aged Actions. Treatment Outcome Actions. Substances Dextromethorphan Actions.
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The Therapeutic Effect of Adding Dextromethorphan to Clonidine for Reducing Symptoms of Opioid Withdrawal: A Randomized Clinical Trial