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European Association of Urology guidelines state that adjuvant inguinal radiotherapy AIRT is "not generally recommended".
Despite this, many centres continue to offer AIRT to a subset of men. Primary outcomes were relapse-free survival and toxicity. Risk of bias assessment was undertaken. Evidence synthesis: A total of abstracts were identified and screened independently by two reviewers. Seven studies were eligible for inclusion: six full-text manuscripts and one conference abstract. All were retrospective series and at a high risk of bias. The selected studies included men. Indications for AIRT varied but were typically involvement of two or more inguinal nodes or extranodal extension.
Regional recurrence rate following AIRT was reported at Only one study reported on toxicity. Conclusions: The evidence indicates that men treated with AIRT do not gain benefit with respect to relapse or survival. Uncertainty remains due to the retrospective nature and high risks of bias across the evidence.
Given the lack of evidence supporting AIRT, it cannot be recommended for routine practice. Patient summary: Men with penile cancer who have involvement of the inguinal lymph nodes are at a high risk of cancer recurrence and death. We reviewed the literature to see if radiation treatment after removal of the nodes provided benefit.
We did not find any good-quality evidence supporting this treatment, and hence it cannot be recommended. Keywords: Adjuvant radiotherapy; Lymph nodes; Penile cancer. Published by Elsevier B. All rights reserved. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable.
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Epub Sep PMID: No abstract available. Similar articles Management of the lymph nodes in penile cancer. Heyns CF, et al. PMID: Review. Lymphadenectomy in the surgical management of penile cancer. Protzel C, et al. Eur Urol. Epub Feb Azizi M, et al. Eur Urol Focus. Epub Jun Long-term followup of penile carcinoma with high risk for lymph node invasion treated with inguinal lymphadenectomy. Marconnet L, et al. PMID: Lymph node metastasis in intermediate-risk penile squamous cell cancer: a two-centre experience.
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Publication types Systematic Review Actions. Humans Actions. Inguinal Canal Actions. Lymph Nodes Actions. Lymphatic Metastasis Actions. Male Actions. Neoplasm Staging Actions. Practice Guidelines as Topic Actions.Kind man w Aberdeen penis
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